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GHDDI is growing rapidly to build its capability and capacity in performing drug discovery activities. We are seeking talented scientists and staff, as well as management and operations experts to join us. We provide outstanding career opportunities for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

If you are interested in working at GHDDI, please contact us at
career@ghddi.org

Lab Manager Assistant  

Key Responsibilities

  • The initial responsibility is to provide services for lab including lab supplies, critical sample storage, etc. according to user-requests.

  • Assist in handling daily office paperwork relating to sample import and export, account application, facility projects, etc.

  • Be responsible for routine cell culture, strictly abide by the standard operating procedures to complete cell preparation, culture, passage, cryopreservation and detection.

  • Assist in Coordinating installation, training, and maintenance of lab equipment. Certify instrument performance; arrange equipment replacement, service, and repair.

  • Competent for other temporary work assigned by leaders.


Minimum Requirements

  • BS or college degree in biology or related field.

  • 2 years working experience in institute or industry.

  • Familiar with lab equipment and supplies.

  • Skilled in office software and data statistical analysis capabilities.

  • Ability to work with people with diverse background.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Research Associate (Microbiologist), Disease Biology  

Key Responsibilities

  • Perform isolation and cultivation of microorganisms, drug resistance detection, susceptibility test and MIC determination as well as other biological experimentation and assay development for high-throughput screening.

  • Conduct microbiological experiments in BSL2 environment; most works involve a variety of human pathogenic bacteria and viruses.

  • Assist other scientists in microbial genetic manipulation and other routine lab procedures and maintenance as assigned by supervisor.


Minimum Requirements

  • Master-level graduate or outstanding Bachelor major in Microbiology, Molecular biology, Biochemistry or other related discipline.

  • Proficient in experiments related to classical Microbiology, such as microorganism cultivation, isolation and identification, bacterial staining, various microscopy techniques, growth curve, serial dilution and plate counting, drug MIC determination and statistical analysis of microbiological data. Strong knowledge and experience in basic molecular biology, such as cloning, DNA sequence analysis, protein expression, purification, and Western blotting.

  • Experience in cultivation of pathogens or anaerobes for HTS would be a plus.

  • Candidates must be highly self-motivated, and have good problem solving and interpersonal skills, with the ability to work well with members of the research and management teams in a dynamic and highly collaborative environment. S/he should be able to communicate in English.

  • Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist/ Investigator (Host Immune Defense), Disease Biology  

Key Responsibilities

  • Study the host response and mechanism of action to infection in various infectious diseases including TB, malaria, viral infection and other public health diseases.

  • Identify the interacting signaling pathways and the key proteins in host cells in responding to pathogens and other environmental challenges.

  • Isolate and establish primary immuno-cell culture based on the special properties of various types of immune cells.

  • In collaboration with assay development group to identify biochemical or cellular assays to screen for cmpds improving host immune system against challenges.

  • Develop additional assays for hit validation and triage.

  • Work closely with medichem group to examine in vitro efficacy of cmds as a guidance to SAR.

  • Responsibilities may vary depending on the training background and experience.


Minimum Requirements

  • PhD degree in immunology, cell biology, molecular biology or the related biological sciences with 0-6 year experience.

  • In depth understanding of and working experience with human innate and/or adaptive immune-regulation.

  • Familiar with immune cell types and their properties/markers and techniques in the field.

  • Good team player, excellent collaboration and communication skills.

  • Oral and written skill of English in scientific communication.

  • Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Research Associate (Parasitic), Disease Biology  

GHDDI has an opportunity available in Disease Biology Group for a biologist with BS or MS degree. We are seeking a dedicated and self-motivated research associate to manage and assist various projects of the Parasitic Disease Biology group at GHDDI.


The applicants will work with multidisciplinary teams, including GHDDI medicinal chemistry, DMPK, and disease biology. Our research projects encompass a wide variety of drug discovery fields, including high throughput compound screenings, mode of action studies (chemical biology), in vitro/silico/vivo pharmacological/toxicological studies, mechanisms of resistant studies (parasite genomics), structure-based drug design, chemoinformatics, lead generation and IND enabling.


Key Responsibilities

  • Strive to run the Parasitic Disease Biology lab efficiently and safely.

  • Organize and direct the daily activities of the laboratory.

  • Maintain various cell cultures and keep cell line inventories.

  • Assist and perform experiments and assays with other scientists.

  • Manage supplies and laboratory inventory and ensure all instrumentations/equipment are functioning properly.


Minimum Requirements

  • Have a BS or MS degree in biology or related area with minimum of 0 to 5 years of research experience.

  • Possess excellent organizational skills and the ability to interact effectively with an international network of laboratories and disease experts.

  • Have basic in vitro cell culture and molecular biology techniques.

  • Be meticulous in maintaining lab notebooks and data files.

  • Have basic English communication skills.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Parasitologists & Microbiogist (various levels), Disease Biology  

Key Responsibilities

  • Design screening cascades and implement HTS, hit triage and interpret the results of DMPK and toxicological profiling.

  • Work closely with medicinal chemistry, structural biology and DMPK teams and help select and advance screening hits.

  • Explore molecular targets (mode of actions) of hit/lead/candidate compounds.

  • Initiate, facilitate and organize domestic and international collaborations with academic and industrial partners.

  • Take a leadership role for data analysis and nominate strategies.

  • Mentor team members and help them trouble shoot.

  • Develop written reports and oral presentations for monthly and quarterly meetings and annual reports.

  • Present findings at international meetings and publish to scientific journals.


Minimum Requirements

  • Have a Ph.D in parasitology, microbiology, vector biology, molecular biology, chemical biology or any related area with minimum of 0-2 years of post-graduate research experiences for the Institute Fellow position and 2 to 7 years experiences for the Scientist or Investigator position. MDs who are interested in tropical medicine/public health or DVMs who are interested in tropical zoonotic/livestock diseases or comparative medicine are also encouraged to apply.

  • Have broad understanding of cutting-edge technologies and challenges in anti-microbial drug discovery for neglected diseases.

  • Have basic knowledge of pre-clinical drug discovery efforts including in vitro/in vivo assay design, compound profiling/triaging, understanding of pharmacokinetics and pharmcodynamics, and medicinal chemistry.

  • Have excellent oral and written English communication skills.

  • Be capable of working in an interactive and multidisciplinary team environment while conducting self-directed research within broader goals set by the group.

  • Possess excellent organizational skills and the ability to interact effectively with an international network of laboratories and disease experts.

  • Be meticulous in maintaining lab notebooks and data files.

  • The applicants should demonstrate a proven track record of scientific achievements and creative problem-solving skills.

  • Those with in-depth knowledge in genome editing, chemical biology, systems biology, parasite genomics, biomarker discovery, host immunity, vector biology, or in vivo animal model studies will be preferred.

  • Hands-on experiences in in vitro cell culture, microscopy, flow cytometry and molecular biology are ideal, but not required.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Veterinary Research Associate (Comparative Medicine), Disease Biology  

GHDDI has an opportunity available in Comparative Medicine Group for a veterinary research associate with a BS or MS degree. We are seeking an experienced and responsible veterinary scientist to support discovery efforts of novel therapeutic agents at GHDDI.


The applicant will work with multidisciplinary teams, including medicinal chemistry, DMPK, and disease biology. Our research projects encompass a wide variety of drug discovery fields, including high throughput compound screenings, mode of action studies (chemical biology), in vitro/silico/vivo pharmacological/toxicological studies, mechanisms of resistant studies (parasite genomics), structure-based drug design, chemoinformatics, lead generation and IND enabling.


Key Responsibilities

  • Organize and direct the daily activities of the vivarium.

  • Maintain multiple immunocompetent and immunodeficient mice.

  • Assist and perform in vivo efficacy studies (parasite inoculation, drug dosing, blood and tissue sampling and in vivo imaging) with other scientists.

  • Manage supplies and vivarium inventory and ensure all instrumentations/equipment are functioning properly.


Minimum Requirements

  • The applicant should:

  • Have a BS or MS degree in biology, animal science or any related area with minimum of 2 years of vivarium experience.

  • Have basic mouse work techniques, including gavage feeding, intraperitoneal and tail vain injections.

  • Have basic English communication skills.

  • Be capable of working in an interactive and multidisciplinary team environment.

  • Possess excellent organizational skills and the ability to interact effectively with an international network of laboratories and disease experts.

  • Be meticulous in maintaining lab notebooks and data files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Chief Scientific Officer  

About the Chief Scientific Officer

The Chief Scientific Officer (CSO) will be working with the Institute CEO and Board to develop and manage the Institute's scientific R&D. The CSO will be responsible for developing and managing a world class research team to deliver drug candidates for diseases disproportionately impacting the world's poorest populations. Moreover, the CSO will be responsible for establishing and maintaining scientific collaborations with leading organizations in drug discovery and global health product development. The CSO will play a key role in engaging with GHDDI's Scientific Advisory Committee.
We are looking for a candidate with solid and visionary leadership skills and scientific ability, who is enthusiastic about working in a fast paced, dynamic environment. Additionally, this person should be passionate about taking a key role in shaping the vision and direction of a groundbreaking drug discovery institute. The candidate will have a Ph.D. in a relevant scientific discipline. A demonstrated ability to take initiative and engage in innovative problem solving is critical. A successful candidate must have a track record of success in broad drug discovery research and development, supported by publications and external presentations. Candidates must possess strong written and oral communication skills and the ability to drive results.


Key Responsibilities

  • Oversee all drug discovery projects and scientific operations to ensure the organization meets its scientific objectives.

  • Lead and manage the development of annual scientific goals, including obtaining and acting upon inputs from the Board of Directors, the Scientific Advisory Committee and collaborators.

  • Work closely with the CEO and other executives to ensure that the Board of Directors are well informed. Specifically, responsible for reporting and obtaining feedback on scientific objectives to the Board of Directors.

  • Forge deep, lasting relationships with GHDDI collaborators, including Tsinghua University, Calibr, and product development partners, and funding partners including the Bill & Melinda Gates Foundation and the Beijing Science and Technology Innovation Group.

  • Work with the CEO and other executive officers to manage overall business objectives.

  • Set clear expectations, give appropriate autonomy, and guide team members; manage performance by providing feedback, guidance/teaching, and development opportunities.

  • Ensure up to date knowledge of developments in drug discovery research and practices, and timely dissemination of this knowledge.

  • Ensure that the integrity and profile of GHDDI within the scientific community are maintained at a high level, consistent with the requirements of the business.

  • Develop and ensure that systems, capabilities, and resources are in place to optimize productivity and probability of success of GHDDI scientific team.

  • Oversee the overall management of the laboratory team, such as by ensuring adherence to an agreed upon budget, building and developing a world class team, and identifying technology and other needs.

  • Represent GHDDI in the scientific community, including representing GHDDI at scientific conferences and communicating through scientific presentations and publications.

  • Ensure that GHDDI develops and adheres to policies on Health, Safety and Environment.


Qualifications Education

  • Ph.D. or equivalent in a relevant scientific discipline required.


Required Experience and Skills

  • At least 10 years of drug discovery or development experience in the biotechnology or pharmaceutical industry (or relevant/equivalent experiences in academia), with track record of success.

  • Innovative and strategic thinker.

  • Ability to travel domestically and internationally.

  • Demonstrable ability and enthusiasm for identifying, setting, and meeting critical deliverables.

  • Ability to build strong relationships with key stakeholders.

  • Dynamic self-starter with a drive for results and ability to motivate others to do their best.

  • Ability to celebrate differences and encourage scientific openness and frank discussion.

  • Team oriented and invests in the success of others.

  • Fluent in Chinese and English.


Preferred Qualifications

The ideal candidate will be a seasoned pharmaceutical or biotechnology scientific executive or academic leader with strong drug discovery/translational experiences with:

  • An outstanding record of accomplishment in providing leadership in research organizations, growing a business, and building/managing research collaborations with industry and academia.

  • Strong leadership capabilities.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Disease Biologist (various levels), Disease Biology  

Key Responsibilities

  • Have years of experience and in-depth understanding of infectious diseases and targets, and have the knowledge to strengthen the translational aspects of the projects.

  • Initiate project/target identification. Coordinate all functions to ensure a smooth progress, and make scientific decisions timely.

  • Be responsible for assay development, HTS, biochemical, cellular and other experiment design and performance. Animal model and/or pharmacology experience is a plus.

  • Result driven, multi-task, strong communication and presentation skill.

  • Establish collaboration both internally and externally, provide scientific expertise across functions/teams.


Minimum Requirements

  • PhD degree in biological science with proven record of accomplishment. Or A MS in Biology, at least 3 years working experience. Experience in infectious disease and drug discovery is highly appreciated.

  • Candidates must be highly self-motivated and have good communication skills to work in a collaborative and dynamic team environment. Oral and written ability in English.

  • Leadership skill is required for project leaders scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

DMPK, Platform  

Key Responsibilities

  • The individual will be responsible, working with CROs, to design, analyse, report pharmacokinetic and pharmacodynamics data to support drug discovery programs.

  • Be responsible to assess ADME and physicochemical properties of NCEs, plasma protein binding, permeability, solubility, stability, aggregation, from early leads, preclinic candidate to clinic drug candidate, at all stages of drug discovery process.

  • The DMPK will join project teams at the early stage to ensure effective integration of pharmacokinetics and accelerate the progress and facilitate the translational efforts at the later stage. Make dose assessment in animal models and humans.

  • The DMPK should be familiar with and suggest for formulation methods.

  • Support internal projects and external collaborations in developing project.


Minimum Requirements

  • Ph.D. in Pharmaceutical Sciences, Pharmacology, or related field with a specific focus on pharmacokinetics.

  • 5 years pharmaceutical industry experience in the conduct of pharmacokinetic and pharmacodynamics support.

  • Desirable to have experience as a team member representing DMPK department on interdisciplinary project teams.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Head of Preclinical and Early Clinical Development  

Key Responsibilities

  • Key member of GHDDI Scientific Leadership Team.

  • Provides overall strategy and direction of preclinical and early clinical trials, processes and procedure.

  • Responsible for coordinating the acquisition of necessary medical/scientific input from outside experts/consultants/advisors.

  • Design preclinic candidate (PCC) development plan and oversee all activities from PCC to IND submission.

  • Identify and execute contracts with appropriate CROs.

  • Prepare and manage budgets.

  • Ensures quality standards are set and maintained over all areas of responsibility.

  • Prepare and assure the overall quality of regulatory submissions to Health Authorities.

  • Attend and present at Investigator Meetings and other meetings as needed.

  • Collaborate with relevant GHDDI departments to ensure smooth transition from discovery to preclinical studies.

  • Interact with Gates Medical Research Institute (GMRI) and other organizations for early development programs.


Minimum Requirements

  • MD, MD/PhD or equivalent with extensive with at least 10 years pre- and early clinical study experiences.

  • Capable of working independently within a highly matrixed environment.

  • Experience in collaborating across multiple organizations.

  • Experience in budgetary management and decision making.

  • Demonstrated effective negotiating, influencing, interpersonal and leadership skills.

  • Ability of managing and interactions with external CROs, consultants and other contract organizations.

  • Exceptional verbal and written communication and presentation skills.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

HTS Automation (Leader and various levels), Lead Generation  

Key Responsibilities

  • Set up and maintain automated HTS platform.

  • Troubleshoot, operate, and maintain HTS automation system.

  • Extensive experience with hardware such as automation, screening facilities, as well as software, i.e. data processing and management.

  • Manage the automation / informatics, provide flexible and adaptive support of research goals.

  • Establish collaboration both internally and externally, provide technical expertise across functions/teams.


Minimum Requirements

  • Ph.D. or MS with equivalent experience in Biology or Engineering or relevant field, a few years working experience in the function of assay automation.

  • Familiar with HTS workflows, protocol design and automation software.

  • Familiar with early stage drug discovery practices is a plus.

  • The candidate must be highly self-motivated and have good communication skills to work in a collaborative team environment. Oral and written skills in English is required.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Institute Fellow/ Scientist (Artificial Intelligence), Computational Chemistry  

Key Responsibilities

  • Explore novel algorithms for small molecule drug discovery using artificial intelligence.

  • Build a multifunctional AI enabling technology platform to help expedite drug discovery process.

  • Construct an in-house comprehensive database with continuous expanding capability using data mining and data integration technology.

  • Apply AI-based methods to internal drug discovery projects.


Minimum Requirements

  • PhD degree in Computational Chemistry, Bioinformatics, Computer Science or related disciplines with a record of demonstrated productivity.

  • Basic understanding of machine learning/deep learning with hands-on experience preferred.

  • Good understanding and coding experience of the Python language, experience with other object-oriented language is a plus.

  • Experience with drug discovery is plus.

  • The candidate must have good communication skills to work in a collaborative team environment. Oral and written skills in English are preferred.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Investigator and above, Medicinal Chemistry  

Key Responsibilities

  • Lead the medicinal chemistry activities of one or more small-molecule drug discovery projects at target validation, hit to lead or lead optimization stages.

  • Work together with core team members across multiple disciplines to design and implement project strategies for the advancement of projects leading to the identification of high-quality preclinical candidates.

  • Independently design biologically active molecules and conduct SAR studies to meet the project goals; design synthetic routes and lead the internal or external chemistry team in the synthesis and characterization of drug candidates for the projects.

  • Work with computational chemistry group to develop structure-based target molecules for projects.

  • Proactively communicate project strategy, critical issues and recommendations to enable appropriate resource decisions.

  • Provide supervision, scientific mentorship and technical training of the team members.

  • Maintain excellent communication across internal and external team members.


Minimum Requirements

  • Ph.D. in chemistry or related discipline.

  • A minimum of five years of experience in medicinal chemistry required; candidates with demonstrable hands-on small molecule drug discovery and pre-clinical development experience in pharmaceutical/biotech industry highly desired.

  • Strong track record of individual and team-level contributions to the discovery and pre-clinical development of small molecule clinical candidates supported with high impact publications, oral presentations and patent applications.

  • Excellent background and expertise in organic chemistry with a high level of synthetic skill including novel route design is essential.

  • Demonstrated project leadership experience in leading all stages of small molecule drug discovery with the ability to define strategy and critical decision making.

  • Excellent problem solving and interpersonal skills with the ability to work well with members of the research and management teams in a dynamic and highly collaborative environment.

  • Experience in leading and collaborating with chemistry teams from CROs is a plus but not required.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Manager/Sr. Manager, R&D External Innovation  

Key Responsibilities

  • Search, identify and assess potential R&D opportunities with external partners which are in align with the Institute’s priorities and strategy.

  • Closely work with various internal functions and disease groups to develop collaborative projects, ensure successful progression and outcome of these projects, and further develop collaboration opportunities.

  • Establish and maintain excellent relationships with external partners worldwide including collaborators, key stakeholders, biotech and pharma companies, and industry and academic KOLs.

  • Responsible for agreements, term sheets and other relevant documents, and negotiating major complex terms and transactions.

  • Conduct financial/business analysis to support external transaction process.

  • Lead execution of potentially multiple types of agreements include research collaboration agreements and supply agreements.

  • Other relevant projects and tasks assigned by Institute leaders.


Minimum Requirements

  • 5+ years of experience in pharmaceuticals industry with at least 2 years of experience in business development or relevant areas.

  • MD or Ph.D. in bio-sciences, medical science, chemistry, pharmaceutical science or equivalent. host-pathogen interaction or cellular immunology is highly appreciated. Hands-on experience in assay development and HTS would be a plus.

  • Skilled at the fundamentals of biotech/pharmaceutical business development – networking, evaluation, partner discussions/negotiations, term sheets, agreements, etc.

  • Strong analytical skills and ability to effectively understand and act on complex information under high time pressure situations.

  • Cross-functional team leadership/project management.

  • Fluent English, strong communication and people skills.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Microbiologist & Immunologist (various levels), Disease Biology  

Key Responsibilities

  • Develop and perform cellular/phenotypic assays for HTS and other biological experiments.

  • Analyze data and work together with chemists to evaluate compound potency by various assays.

  • Target identification, validation and MOA study.

  • Facilitate both internal and external collaborations and provide scientific expertise across functions/teams.


Minimum Requirements

  • PhD with 0-5 years of experience in microbiology, immunology or related discipline.

  • Experience in host-pathogen interaction or cellular immunology is highly appreciated. Hands-on experience in assay development and HTS would be a plus.

  • Candidates must be highly self-motivated and have good communication skills to work in a collaborative and dynamic team environment. Oral and written ability in English is required.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Research Associate, Medicinal Chemistry  

Key Responsibilities

Include but are not limited to:

  • Independently carry out efficient synthesis, purification and characterization of drug candidates for target validation, hit-to-lead and lead optimization projects.

  • Participate in the experimental plan under the supervision of senior members and assist in preparation of project reports, including final procedures and compiling all analytical data.

  • Performs routine analytical procedures necessary (NMR, LCMS etc.) to support development activities.

  • Manage and operate lab equipment; Maintains laboratory records in compliance with internal policy.

  • Work with internal and external teams to accelerate the project development.


Minimum Requirements

  • M.S. in chemistry or related discipline or B.S. with 1-3 years industry experience in drug discovery.

  • Strong background and experience in organic chemistry (methodology, catalysis, total synthesis etc) is required, along with a proven track record.

  • Demonstrated proficiency in basic laboratory skills (including NMR, LCMS etc) and familiar with Chemistry/Office applications (Chemoffice, Word, Excel, PowerPoint, etc.)

  • Good problem solving and interpersonal skills with the ability to work well with members of the research teams in a dynamic and highly collaborative environment.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientific IT  

Key Responsibilities

  • Work closely with scientists and IT to meet research needs.

  • Be responsible for scientific software rollout, training, customization, applications and trouble shooting.

  • Assess application solutions for laboratory informatics related needs.

  • Provide user interface support, operation and maintenance of laboratory devices and informatics.

  • Facilitate research by including more informatics ideas from a perspective of scientific IT.

  • Help research teams to thoroughly search for and collect any available information needed for projects.

  • Provide consultancy and deliver sustainable computational solutions to routine and/or at hoc requests in a timely manner.

  • Harmonize a professional network environment and promote mutual understanding and relationships among research, operation and IT support.


Minimum Requirements

  • M.S. or Ph.D. in computer science/life science field with a good knowledge of computer and scientific applications.

  • 5+ years data organization and analysis experience using Oracle or similar database.

  • 2+ years hands-on laboratory maintenance and management experience.

  • Experience in software engineering including the development of software.Preferably with a high content of scientific domain knowledge and the development of software for regulated environments.


Personal Skills

  • Initiative-taking: a good communicator and a proactive contributor in leading the lab operations initiatives with excellent communication skills.

  • Customer focus mind-set.

  • Be adaptable to changes, particularly those areas where roles and responsibilities are sometimes ambiguous given the changing needs in an early stage research organization.

  • Ability to complete high quality tasks and meet deadlines.

  • Ability to work independently.

  • English: Skilled to communicate and discuss advanced technical material across functions.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist/ Investigator (Assay Development), Lead Generation  

Key Responsibilities

  • Develop and validate biochemical, biophysical and cellular assays.

  • Biochemical assays include ELISA, alpha assay, TR-FRET, all sorts of functional readout of enzymatic activity and any innovative assay formats.

  • Enable technologies for protein and small compounds biophysical binding evaluation. Technologies include but not limited to ITC, SPR, TSA, NMR etc.

  • Establish cellular assays to evaluate the biological function of pathogens in infectious disease and to monitor the pathogen-host cell interaction in an environment most recapitulating the actual pathological condition.

  • Develop high content imagine based phenotypical screening.

  • Adapt various assays to automated lab equipment for high throughput screening.

  • Validate the established assays to ensure characterization and identification of small compounds.

  • Data analysis and management using standard software as well as customized sophisticated software.

  • Communicate assay/screening results effectively with teams as necessary.

  • Data analysis and management using standard software as well as customized sophisticated software.

  • Follow up and evaluate new technologies and methods developed in both academic labs and industry.


Minimum Requirements

  • Ph.D. in biology or related field, a few years working experience in assay development, preferentially in an industrial setting.

  • Leadership and hands experience in biochemical, biophysical and cellular assay development.

  • Familiar with screening automation and software.

  • The candidate must be highly self-motivated and have good communication skills to work in a collaborative team environment. Oral and written skills in English is required.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist/ Investigator (Biological Chemist & Pharmacologist), Disease Biology  

Key Responsibilities

  • Perform determination of the mode of action of antibacterial small molecules.

  • Responsible for target identification, using systems biology techniques involving transcriptomics, proteomics and metabolomics.

  • Develop novel biochemical assays for analysis of multi-component systems such as transcription, translation, respiration and cell membrane/wall biosynthesis.

  • Library screening, validation and data analysis.


Minimum Requirements

  • Master or PhD degree in molecular biology, biochemistry, microbial genetics, physiology or the related biological sciences with 0-6 year experience.

  • Hands-on experience in programming and data science is highly appreciated. Knowledge and experience in whole-cell level characterization would be a plus.

  • Good team player, excellent collaboration and communication skills.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist/ Investigator (Compound Management), Lead Generation  

Key Responsibilities

  • Set up and maintain compound library management.

  • Extensive experience with hardware such as storage automation, liquid handling instrument, as well as software, i.e. inventory record and management.

  • Support compound handling methods and processes to enable efficient execution of research activities.

  • Establish collaboration both internally and externally, provide technical expertise across functions/teams.


Minimum Requirements

  • Ph.D. or MS with experience in the function of compound management.

  • Familiar with compound management workflows, protocol design and automation software.

  • The candidate must be highly self-motivated and have good communication skills to work in a collaborative team environment. Oral and written skills in English is required.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist/ Investigator (Biophysicist & Structural Biologist), Platform  

Key Responsibilities

  • The candidate should have hands on experience on Biacore SPR analysis or hands on experience on Cryo-EM manipulation with 1-6 years of post-doc or working experience in life science or drug discovery.

  • A person in this role should have in-depth understanding and hands on experience in protein expression, purification in various systems, protein-compound co-crystallography and structure solving.

  • He/she will work closely with computer aided drug design team, provide input for medicinal chemistry.

  • Result driven, strong communication and presentation skill.

  • Establish collaboration both internally and externally, provide technical expertise across functions/teams.


Minimum Requirements

  • Ph.D. degree in Structure Biology, drug discovery or membrane protein experience is a plus.

  • The candidate must be highly self-motivated and have good communication skills in English, and work in a collaborative team environment.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist/ Investigator, Computational Chemistry  

Key Responsibilities

  • Homology modelling and refinement.

  • Assist target validation.

  • Perform virtual high throughput screening and prioritize top compounds for experimental tests.

  • Guide hit-to-lead and lead optimization.

  • Develop novel methodologies to tackle challenging but important problems to better support CADD effort.

  • Work closely with medicinal chemists, structural biologists and other functionalities in the institute.


Minimum Requirements

  • PhD degree in Computational Chemistry with a record of demonstrated productivity.

  • Minimum 1~3 years of experience with structure-based drug design and 3 years above experience in pharma company is a plus.

  • The candidate must have good communication skills to work in a collaborative team environment. Oral and written skills in English are preferred.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Scientist, Medicinal Chemistry  

Key Responsibilities

Include but are not limited to:

  • Act as a leader in the laboratory, executing on program and chemistry strategy.

  • Independently design and carry out efficient synthesis, purification and characterization of drug candidates for target validation, hit-to-lead and lead optimization projects.

  • Develop and apply innovative synthetic and medicinal chemistry problem solving skills to build structure-activity relationships.

  • Work under supervision of senior members to design biologically active molecules and conduct SAR studies to meet the project goals.

  • Work with computational chemistry group to develop structure-based target molecules for projects.

  • Provide scientific mentorship and technical training of the team members.

  • Supervise and manage the external chemistry team to execute all chemistry plan on projects with superb performance.

  • Establish a substantial external scientific presence including authoring significant scientific publications and presentations.


Minimum Requirements

  • Ph.D. in chemistry or related discipline with a minimum of one-year industry experience in drug discovery.

  • Strong background and experience in organic chemistry (methodology, catalysis, total synthesis etc) is required, along with a proven track record of solving complex problems.

  • Good problem solving and interpersonal skills with the ability to work well with members of the research teams in a dynamic and highly collaborative environment.

  • Experience in leading and collaborating with CRO chemistry teams is a plus.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

Assistant to CSO  

Key Responsibilities

  • Support CSO and the whole R&D team to deal with the routine documentation work and administrative work efficiently, including schedule meeting, record meeting minutes, arrange travels, maintain files and record, prepare presentation materials etc.

  • Track and review the expenses report for the department.

  • Coordinate with internal departments and external third parties basing the work needs.

  • Coordinate and collect scientific information to assist in writing regular or ad hoc progress reports to GHDDI partners and key stakeholders.

  • Participate or lead special or ad hoc projects being assigned.


Minimum Requirements

  • At least Bachelor degree in Secretary, Administration or other equivalent education.

  • Fluency in spoken and written English.

  • Good MS Office operation skills, such as Word/Excel/PowerPoint/etc.

  • Strong communication and interpersonal skills.

  • MNC working experience is preferred.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org