JOIN US

GHDDI is growing rapidly to build its capability and capacity in performing drug discovery activities. We welcome talented scientists and researchers, as well as managerial and operations experts to join us. We provide outstanding career opportunities for motivated and talented individuals who share GHDDI’s vision and are committed to making a difference in science and human healthcare.

If you are interested in working at GHDDI, please contact us at
career@ghddi.org

Lab Animal Technician  

主要职责

  • 负责实验动物的日常管理及相关工作;

  • 按公司标准规范及项目要求和培训要求操作各项动物实验,包括:动物给药、动物采血、动物处理、动物血清检测等相关工作;

  • 及时、准确和清楚的进行实验观察及数据记录;

  • 参与或配合相关研发工作;


任职要求

  • 兽医学、动物医学、生物学等相关专业,大专及以上学历

  • 至少有一年以上动物实验相关工作经验;

  • 掌握基本的动物实验操作技能;

  • 责任心强,能吃苦耐劳。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

Lab Animal Caregiver  

主要职责

  • 负责实验动物的饲喂及日常观察;

  • 负责日常实验动物笼具、工作服、工作鞋的清洗和消毒;

  • 负责垫料库、饲料库的日常卫生清洁和消毒;

  • 负责动物房的日常卫生清洁和消毒;

  • 负责动物房环境参数及相关工作日志的记录;

  • 高压灭菌器的使用和维护。

  • 针对动物实验过程中出现的异常情况及时向上级汇报;

  • 完成上级主管交办的其他工作。


任职要求

  • 动物医学或实验动物相关专业,中专以上学历;

  • 至少有一年以上实验动物饲养工作经验,

  • 积极主动、认真细致、责任心强;

  • 学习能力强,能承受一定压力,有团队合作精神;

  • 身体健康,没有任何传染性疾病。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

Open Rank Scientist, EED/Gut Health Program, Disease Biology  

Key Responsibilities

  • Establish cellular models (regular monolayer, co-culture and 3D organoid culture) for gut disease target and tool evaluation

  • Develop relative assays to evaluate compounds and any other potential hits

  • Execute research plans, evaluate and conclude the data from the analysis, focus on drug discovery in various aspects of gut disease/health project.

  • Design and lead experiments to move project

  • Provide biology and technology expertise involving examining new techniques to improve existing analysis and provide additional capabilities. Contribute to individual project(s) as well as the overall program

  • Present results in writing report and oral presentation

  • Work cooperatively within organization and with external partners


Minimum Requirements

  • Ph.D./Master’s degree in Immunology, Cell Biology, Microbiology, Biomedical Sciences or related field

  • Research experience in gut health/disease required, such as environmental enteric dysfunction (EED) inflammatory bowel disease, celiac disease, irritable bowel syndrome; intestinal stem cell and health, gut barrier, inflammation; host defense, microbiology, gut microbiota/Microbiome

  • Hands-on experience with molecular biology, biochemical and cell-based assays; experience in stem cell,organoid model and in drug discovery is a plus.

  • Results-focused and creative bench scientist with strong problem-solving skills

  • Demonstrated ability to design experiments, make detailed observations, analyze data, interpret results and deliver timely results

  • Oral and written skills in English is required.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Open rank Scientist,Bioinformatics  

Key Responsibilities

  • Be able to handle large data sets including DNA/RNA seq, NGS assembly, omics data such as proteomics, PDB, etc.

  • Perform sequence/omics data analysis etc to help with genome annotation and functional/metabolic pathway analysis. Relevant areas include (but are not limited to) metagenomics, metabolomics, proteomics and other omics

  • Perform information search and collection for relevant targets or projects in publication, conference, communication and any other resources

  • Assist target identification, selection and validation

  • Help with mutation and drug resistance analysis

  • Develop novel methodologies/workflow by combining bioinformatics, AI and physics-based approaches to help lower resistance rate

  • Refine available or develop novel methods for drug target identification

  • Work closely with project teams to understand the requirement and help interpret data and results


Minimum Requirements

  • Master or PhD degree in Bioinformatics/Computational biology with a record of demonstrated productivity.

  • Experience in drug discovery is a plus

  • Coding experience is preferred

  • The candidate must have good communication skills to work in a collaborative team environment. Oral and written skills in English are preferred.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Big Data Engineer/Data Scientist  

Key Responsibilities

  • Write reusable, testable, and efficient code based on project requirement and existing source code

  • Implement in-house big data application involving data integration, data mining and natural language processing based on pre-designed architecture

  • Implement Front and Back-end of AI applications based on pre-designed algorithm and architecture.


Minimum Requirements

  • Strong understanding and coding experience of Python is required, experience with other object-oriented language such as Java, C++ etc., is a plus.

  • Good understanding of data structure, able to process and integrate multiple structured/unstructured data sources and databases into one data system, fluent in SQL or similar data processing language.

  • Good understanding of relational database (SQL based) and big data (Hadoop/Spark) architecture and able to create database schemas and perform routine database operations based pre-designed protocol.

  • Majored in computer science, software engineering, mathematics, electric engineering or similar disciplines. Having a B.S. or M.S. degree is a plus

  • A good understanding of Machine learning/Deep learning and Natural Language Processing algorithms is a plus

  • Experience with Deep Learning framework, e.g. pytorch, tensorflow is a plus

  • Experience with pharmaceutical industry software and database development is a plus


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Open rank Scientist, Artificial Intelligence/Computational Biology  

Key Responsibilities

  • Explore novel algorithms for small molecule drug discovery using artificial intelligence.

  • Build a multifunctional AI enabling technology platform to help expedite drug discovery process.

  • Construct an in-house comprehensive database with continuous expanding capability using data mining and data integration technology.

  • Apply AI-based methods to internal drug discovery projects.


Minimum Requirements

  • PhD degree in Computational Chemistry,Bioinformatics,Computer Science or related disciplines with a record of demonstrated productivity.

  • Basic understanding of machine learning/deep learning with hands-on experience preferred.

  • Good understanding and coding experience of the Python language, experience with other object-oriented language is a plus.

  • Experience with drug discovery is plus.

  • The candidate must have good communication skills to work in a collaborative team environment. Oral and written skills in English are preferred.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Open Rank Scientist (3D organoid screening), Disease Biology  

Key Responsibilities

  • Establish human patient sample or hESC/iPSC derived 3D organoid culture of various tissues including intestine, liver and others
  • Work together with project teams to develop phenotypical/functional assays for drug screening in the organoid culture to better recapitulate the physiological or pathological condition
  • Interact with screening team for assay optimization, miniaturization and automation
  • Establish collaboration with both domestic and international partners
  • Provide input and feedback to project teams

Minimum Requirements

  • Ph.D. in cell biology or related field
  • Training in stem cell biology, hands on experience in directed differentiation and/or reprogramming
  • Experience with co-culture and cell engineering, 3D culture experience is highly appreciated
  • Good understanding of drug discovery in infectious diseases
  • Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.

Location
Beijing, China

About Us
Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.
GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact
If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org

 * The position is eligible for "Employee Referral Program".

CSO/ Head of R&D/ VP of R&D  

CSO/ Head of R&D/ VP of R&D

The CSO/ Head of R&D/ VP of R&D will be working with the Institute CEO and Board to develop and manage the Institute's scientific R&D. The CSO/ Head of R&D/ VP of R&D will be responsible for developing and managing a world class research team to deliver drug candidates for diseases disproportionately impacting the world's poorest populations. Moreover, the CSO/ Head of R&D/ VP of R&D will be responsible for establishing and maintaining scientific collaborations with leading organizations in drug discovery and global health product development. The CSO/ Head of R&D/ VP of R&D will play a key role in engaging with GHDDI's Scientific Advisory Committee.
We are looking for a candidate with solid and visionary leadership skills and scientific ability, who is enthusiastic about working in a fast paced, dynamic environment. Additionally, this person should be passionate about taking a key role in shaping the vision and direction of a groundbreaking drug discovery institute. The candidate will have a Ph.D. in a relevant scientific discipline. A demonstrated ability to take initiative and engage in innovative problem solving is critical. A successful candidate must have a track record of success in broad drug discovery research and development, supported by publications and external presentations. Candidates must possess strong written and oral communication skills and the ability to drive results.


Key Responsibilities

  • Oversee all drug discovery projects and scientific operations to ensure the organization meets its scientific objectives.

  • Lead and manage the development of annual scientific goals, including obtaining and acting upon inputs from the Board of Directors, the Scientific Advisory Committee and collaborators.

  • Work closely with the CEO and other executives to ensure that the Board of Directors are well informed. Specifically, responsible for reporting and obtaining feedback on scientific objectives to the Board of Directors.

  • Forge deep, lasting relationships with GHDDI collaborators, including Tsinghua University, Calibr, and product development partners, and funding partners including the Bill & Melinda Gates Foundation and the Beijing Science and Technology Innovation Group.

  • Work with the CEO and other executive officers to manage overall business objectives.

  • Set clear expectations, give appropriate autonomy, and guide team members; manage performance by providing feedback, guidance/teaching, and development opportunities.

  • Ensure up to date knowledge of developments in drug discovery research and practices, and timely dissemination of this knowledge.

  • Ensure that the integrity and profile of GHDDI within the scientific community are maintained at a high level, consistent with the requirements of the business.

  • Develop and ensure that systems, capabilities, and resources are in place to optimize productivity and probability of success of GHDDI scientific team.

  • Oversee the overall management of the laboratory team, such as by ensuring adherence to an agreed upon budget, building and developing a world class team, and identifying technology and other needs.

  • Represent GHDDI in the scientific community, including representing GHDDI at scientific conferences and communicating through scientific presentations and publications.

  • Ensure that GHDDI develops and adheres to policies on Health, Safety and Environment.


Qualifications Education

  • Ph.D. or equivalent in a relevant scientific discipline required.


Required Experience and Skills

  • At least 10 years of drug discovery or development experience in the biotechnology or pharmaceutical industry (or relevant/equivalent experiences in academia), with track record of success.

  • Innovative and strategic thinker.

  • Ability to travel domestically and internationally.

  • Demonstrable ability and enthusiasm for identifying, setting, and meeting critical deliverables.

  • Ability to build strong relationships with key stakeholders.

  • Dynamic self-starter with a drive for results and ability to motivate others to do their best.

  • Ability to celebrate differences and encourage scientific openness and frank discussion.

  • Team oriented and invests in the success of others.

  • Fluent in Chinese and English.


Preferred Qualifications

The ideal candidate will be a seasoned pharmaceutical or biotechnology scientific executive or academic leader with strong drug discovery/translational experiences with:

  • An outstanding record of accomplishment in providing leadership in research organizations, growing a business, and building/managing research collaborations with industry and academia.

  • Strong leadership capabilities.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Head of Preclinical and Early Clinical Development (Director/VP)  

Key Responsibilities

  • Key member of GHDDI Scientific Leadership Team.

  • Provides overall strategy and direction of preclinical and early clinical trials, processes and procedure.

  • Responsible for coordinating the acquisition of necessary medical/scientific input from outside experts/consultants/advisors.

  • Design preclinic candidate (PCC) development plan and oversee all activities from PCC to IND submission.

  • Identify and execute contracts with appropriate CROs.

  • Prepare and manage budgets.

  • Ensures quality standards are set and maintained over all areas of responsibility.

  • Prepare and assure the overall quality of regulatory submissions to Health Authorities.

  • Attend and present at Investigator Meetings and other meetings as needed.

  • Collaborate with relevant GHDDI departments to ensure smooth transition from discovery to preclinical studies.

  • Interact with Gates Medical Research Institute (GMRI) and other organizations for early development programs.


Minimum Requirements

  • MD, MD/PhD or equivalent with extensive with at least 10 years pre- and early clinical study experiences.

  • Capable of working independently within a highly matrixed environment.

  • Experience in collaborating across multiple organizations.

  • Experience in budgetary management and decision making.

  • Demonstrated effective negotiating, influencing, interpersonal and leadership skills.

  • Ability of managing and interactions with external CROs, consultants and other contract organizations.

  • Exceptional verbal and written communication and presentation skills.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Investigator (autophagy), Disease Biology  

Key Responsibilities

  • Explore the host autophagy system and innate immune for pathogen clearance.

  • Lead a group of scientists to set up a variety of cellular systems to evaluate the hypothesis.

  • Identify the interaction between host and the pathogens, particularly the specific proteins involved.

  • Design experiment to prove the concept.

  • Engage other functions in drug discovery to drive the project into pipeline.

  • Coordinate with collaborators and CROs.


Minimum Requirements

  • PhD degree in cell biology, molecular biology, biochemistry or related biological sciences with over 6 year experience, with solid training and good tracking record.

  • Hands-on experience in a variety of cell cultures, knowledge and experience in autophagy and innate immune system.

  • Demonstrated leadership and presentation skill.

  • Good team player, excellent collaboration and communication skills.

  • Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Scientist/ Investigator (Host Immune Defense), Disease Biology  

Key Responsibilities

  • Study the host response and mechanism of action to infection in various infectious diseases including TB, malaria, viral infection and other public health diseases.

  • Identify the interacting signaling pathways and the key proteins in host cells in responding to pathogens and other environmental challenges.

  • Isolate and establish primary immuno-cell culture based on the special properties of various types of immune cells.

  • In collaboration with assay development group to identify biochemical or cellular assays to screen for cmpds improving host immune system against challenges.

  • Develop additional assays for hit validation and triage.

  • Work closely with medichem group to examine in vitro efficacy of cmds as a guidance to SAR.

  • Responsibilities may vary depending on the training background and experience.


Minimum Requirements

  • PhD degree in immunology, cell biology, molecular biology or the related biological sciences with 0-6 year experience.

  • In depth understanding of and working experience with human innate and/or adaptive immune-regulation.

  • Familiar with immune cell types and their properties/markers and techniques in the field.

  • Good team player, excellent collaboration and communication skills.

  • Oral and written skill of English in scientific communication.

  • Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world's most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Disease Biologist (various levels), Disease Biology  

Key Responsibilities

  • Have years of experience and in-depth understanding of infectious diseases and targets, and have the knowledge to strengthen the translational aspects of the projects.

  • Initiate project/target identification. Coordinate all functions to ensure a smooth progress, and make scientific decisions timely.

  • Be responsible for assay development, HTS, biochemical, cellular and other experiment design and performance. Animal model and/or pharmacology experience is a plus.

  • Result driven, multi-task, strong communication and presentation skill.

  • Establish collaboration both internally and externally, provide scientific expertise across functions/teams.


Minimum Requirements

  • PhD degree in biological science with proven record of accomplishment. Or A MS in Biology, at least 3 years working experience. Experience in infectious disease and drug discovery is highly appreciated.

  • Candidates must be highly self-motivated and have good communication skills to work in a collaborative and dynamic team environment. Oral and written ability in English.

  • Leadership skill is required for project leaders scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Investigator and above, Medicinal Chemistry  

Key Responsibilities

  • Lead the medicinal chemistry activities of one or more small-molecule drug discovery projects at target validation, hit to lead or lead optimization stages.

  • Work together with core team members across multiple disciplines to design and implement project strategies for the advancement of projects leading to the identification of high-quality preclinical candidates.

  • Independently design biologically active molecules and conduct SAR studies to meet the project goals; design synthetic routes and lead the internal or external chemistry team in the synthesis and characterization of drug candidates for the projects.

  • Work with computational chemistry group to develop structure-based target molecules for projects.

  • Proactively communicate project strategy, critical issues and recommendations to enable appropriate resource decisions.

  • Provide supervision, scientific mentorship and technical training of the team members.

  • Maintain excellent communication across internal and external team members.


Minimum Requirements

  • Ph.D. in chemistry or related discipline.

  • A minimum of five years of experience in medicinal chemistry required; candidates with demonstrable hands-on small molecule drug discovery and pre-clinical development experience in pharmaceutical/biotech industry highly desired.

  • Strong track record of individual and team-level contributions to the discovery and pre-clinical development of small molecule clinical candidates supported with high impact publications, oral presentations and patent applications.

  • Excellent background and expertise in organic chemistry with a high level of synthetic skill including novel route design is essential.

  • Demonstrated project leadership experience in leading all stages of small molecule drug discovery with the ability to define strategy and critical decision making.

  • Excellent problem solving and interpersonal skills with the ability to work well with members of the research and management teams in a dynamic and highly collaborative environment.

  • Experience in leading and collaborating with chemistry teams from CROs is a plus but not required.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Scientist, Medicinal Chemistry  

Key Responsibilities

Include but are not limited to:

  • Act as a leader in the laboratory, executing on program and chemistry strategy.

  • Independently design and carry out efficient synthesis, purification and characterization of drug candidates for target validation, hit-to-lead and lead optimization projects.

  • Develop and apply innovative synthetic and medicinal chemistry problem solving skills to build structure-activity relationships.

  • Work under supervision of senior members to design biologically active molecules and conduct SAR studies to meet the project goals.

  • Work with computational chemistry group to develop structure-based target molecules for projects.

  • Provide scientific mentorship and technical training of the team members.

  • Supervise and manage the external chemistry team to execute all chemistry plan on projects with superb performance.

  • Establish a substantial external scientific presence including authoring significant scientific publications and presentations.


Minimum Requirements

  • Ph.D. in chemistry or related discipline with a minimum of one-year industry experience in drug discovery.

  • Strong background and experience in organic chemistry (methodology, catalysis, total synthesis etc) is required, along with a proven track record of solving complex problems.

  • Good problem solving and interpersonal skills with the ability to work well with members of the research teams in a dynamic and highly collaborative environment.

  • Experience in leading and collaborating with CRO chemistry teams is a plus.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Research Associate, Medicinal Chemistry  

Key Responsibilities

Include but are not limited to:

  • Independently carry out efficient synthesis, purification and characterization of drug candidates for target validation, hit-to-lead and lead optimization projects.

  • Participate in the experimental plan under the supervision of senior members and assist in preparation of project reports, including final procedures and compiling all analytical data.

  • Performs routine analytical procedures necessary (NMR, LCMS etc.) to support development activities.

  • Manage and operate lab equipment; Maintains laboratory records in compliance with internal policy.

  • Work with internal and external teams to accelerate the project development.


Minimum Requirements

  • M.S. in chemistry or related discipline.with industry experience preferred.

  • Strong background and experience in organic chemistry (methodology, catalysis, total synthesis etc) is required, along with a proven track record.

  • Demonstrated proficiency in basic laboratory skills (including NMR, LCMS etc) and familiar with Chemistry/Office applications (Chemoffice, Word, Excel, PowerPoint, etc.)

  • Good problem solving and interpersonal skills with the ability to work well with members of the research teams in a dynamic and highly collaborative environment.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Scientist/ Investigator, Computational Chemistry  

Key Responsibilities

  • Homology modelling and refinement.

  • Assist target validation.

  • Perform virtual high throughput screening and prioritize top compounds for experimental tests.

  • Guide hit-to-lead and lead optimization.

  • Develop novel methodologies to tackle challenging but important problems to better support CADD effort.

  • Work closely with medicinal chemists, structural biologists and other functionalities in the institute.


Minimum Requirements

  • PhD degree in Computational Chemistry with a record of demonstrated productivity.

  • Minimum 1~3 years of experience with structure-based drug design and 3 years above experience in pharma company is a plus.

  • The candidate must have good communication skills to work in a collaborative team environment. Oral and written skills in English are preferred.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".

Artificial Intelligence Research Scientist/Engineer  

The artificial intelligence group of Global Heath Drug Discovery Institute (GHDDI) is looking for experienced algorithm researchers and engineers in the area of artificial intelligence and data science.

  • AIDD (AI for Drug Discovery) is a newly established division, aiming to revolve and accelerate drug discovery process with leading-edge artificial intelligence technologies.

  • GHDDI identifies and develops innovative approaches to novel medicines for diseases most damaging to populations in the developing world.

  • As the first international independent, not-for-profit research institute in China, GHDDI also pioneers China’s path to a more collaborative future in the sciences.

  • The candidates will have an exciting opportunity to prosper global health with technology and make people’s life better.

Key Responsibilities

  • Apply deep learning methods (classification, regression, ranking, recommendation, as well as graph neural network, semi-supervised learning, reinforcement learning and Bayesian network) to internal drug discovery projects.

  • Explore novel AI-based algorithms for small molecule drug discovery.

  • Build the multifunctional AI enabling platform to help expedite drug discovery process.


Minimum Requirements

  • Majored in computer science, electrical engineering, mathematics, or equivalent field, MS or PhD desirable.

  • Experienced in at least one of the following fields: traditional machine learning, deep learning, computer vision, natural language processing, knowledge graph, computational chemistry, bioinformatics.

  • Experienced with programming languages: C or C++, Python.

  • Strong teamwork and interpersonal skills.

  • Action oriented with strong analytical and problem-solving skills.


Preferred Qualifications

  • Strong research and publication record.

  • Experienced with at least one of the following deep learning frameworks: Pytorch, Tensorflow, Theano, Caffe/Caffe2.

  • Strong oral and written skills in English.

  • Experience with drug discovery research is a plus.

Location

Beijing, China


About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.


Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org


 * The position is eligible for "Employee Referral Program".