关于GHDDI博士后工作站

GHDDI于2021年获批设立博士后工作站，与清华大学药学院联合招收及培养博士后，为有志从事创新药物研发的博士毕业生提供广阔的发展平台。GHDDI提供有竞争力的薪酬、年假以及全面社保等福利，并致力于创造一个充满活力、包容和多元化的工作环境，使个人拥有快速成长的发展空间和一份有趣、有价值、有使命感的事业！

2023年博士后招募计划：

职位1：博士后研究员，药物化学

课题方向：

冠状病毒或疟疾小分子药物研发项目在靶点验证、先导阶段和优化阶段中的药物化学研究

专业要求：

药物化学、有机化学等相关学科博士毕业生

职位2：博士后研究员，蛋白质科学

课题方向：

运用生物物理，生物化学，注重于结构生物学的实验技术，对于具有生物学功能的新的蛋白靶点，例如与其他疾病生物学和信息生物学的发现和专注的药物靶点，通过结构功能的解析，辅助药物靶点的筛选，验证以及药物分子的开发。

专业要求：

生物物理，生物化学，结构生物学相关专业博士毕业生，具有晶体学，冷冻电镜，核磁共振，以及其他生物物理和生物化学研究背景优先。

职位3：博士后研究员，疾病生物学(抗病毒组)

课题方向：

通过小分子筛选及分子设计等策略，发展慢性乙型肝炎功能性治愈药物

专业要求：

微生物学、生物工程或基础医学等相关专业博士毕业，有病毒学研究背景者优先

职位4：博士后研究员，高通量筛选平台

课题方向：

建立可同时测量多基因表达的定量分析方法，并将其应用于新药研发早期的靶点发现，靶点验证，和药物作用机理研究。涉及领域包括RNA分析，二代测序， 高通量筛选。

专业要求：

细胞生物学，分子生物学，遗传学，基因组学和生物化学等相关学科博士毕业生

招聘基本要求：

1. 在国内外获得博士学位的应届博士毕业生（申请时须已满足博士学位论文答辩的基本要求），年龄在35岁以下

2. 能全职在本站从事博士后研发工作

3. 博士所从事的研究方向和专业符合本站博士后岗位的要求

为什么选择GHDDI博士后工作站?

1. 您可以探索和了解从早期药物发现至临床前IND研究的全流程并参与其中

2. GHDDI与清华大学药学院双导师制，让您可以与顶尖的国内外工业界及学术界专家一起工作

3. GHDDI良好的学术氛围及文化、丰富的培训及学习机会帮助您快速成长

4. GHDDI国际一流的研发实验平台及全球研发资源网络为您提供广阔视野

5. GHDDI与清华大学药学院实力联动、联合培养模式为您创造更多机会

您可以享受到：

1. 有竞争力的薪酬及全面社保

2. 按博士后管理政策享受出站落户、在站子女入学协助等

3. 带薪年休假及中心其他福利假

4. 补充医疗保险（包括子女）及年度健康体检

5. 博士后出站后可继续在GHDDI工作

申请方式：

请发送个人简历（包含以往研究介绍、论文等）至 career@ghddi.org， 邮件主题中请注明“应聘博士后”及应聘部门。

Key Responsibilities

• Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs.

• Establish robust screening assays to support medicinal chemistry lead optimization programs.

• Design and manage in vivo pre-clinical pharmacokinetics, pharmacodynamics, and toxicity studies.

• Design and manage physiological experiments in translational disease models to test efficacy and mechanism of action of novel clinical candidates.

• Establish PK/PD relationships, demonstrating proof-of-concept, enabling candidate selection and delivering data for clinical dose predictions in preclinical in vivo experiments.

• Establish pharmacology strategy in alignment with company pipeline objectives.

• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way

• Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals.

• Identify, evaluate, and manage vendors for outsourced services and studies.

• Prepare reports for internal and external purposes including regulatory submissions.

• Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.

• Develop and continually advance one’s knowledge base on the molecular pathways being targeted by discovery and development research programs.

• Identify opportunities and develop ideas to enhance and accelerate business processes.

• Cultivates cross-functional relationships with project teams, translational medicine, biomarker teams, and disease-specific working groups to deliver novel targets, biomarkers and drug candidates.

• Responsible for achieving pipeline goals by managing resource allocation and oversight of progress.

• Present scientific accomplishments internally and externally to the scientific community and discussed with key opinion leaders.

• Responsible for career development of team of diverse scientists, contribute to talent strategy and provide mentorship to group.

Minimum Requirements

• PhD in Biology, physiology, pathology or pharmacology with relevant postdoctoral experience and at least 5 years biotech/pharma working experiences.

• Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, and interrogating cellular signal transduction pathways.

• Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.

• Strong background in designing in vivo animal studies.

• Strong knowledge of cell cycle arrest, apoptosis, and senescence.

• Experience in oncology and knowledge p53 signaling pathway is a plus.

• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

• Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Key Responsibilities

• Perform determination of the mode of action of antibacterial small molecules.

• Responsible for target identification, using systems biology techniques involving transcriptomics, proteomics and metabolomics.

• Develop novel biochemical assays for analysis of multi-component systems such as transcription, translation, respiration and cell membrane/wall biosynthesis.

• Develop animal infection models for target validation or efficacy testing.

Minimum Requirements

• Master or PhD degree in molecular biology, biochemistry, microbial genetics, infectious disease or the related biological sciences with 0-6 year experience.

• Knowledge and experience in bacterial infections is highly appreciated. Demonstrable skills in data analysis including programming and statistics would be a plus.

• Good team player, excellent collaboration and communication skills

• Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Key Responsibilities

• Responsible for genetic manipulation with Mycobacterium and/or other bacterial pathogens, developing phenotypic assays and HTS for antibacterial.

• To identify antibacterial drug target, analyze the mode-of-action of small molecule, and bacterial strain typing and genome sequence analysis.

• Develop knowledge to strengthen the medical and pharmaceutical aspects of the projects.

• Facilitate both internal and external collaborations, and provide scientific expertise across functions/teams.

Minimum Requirements

• PhD degree in microbiology or the related biological sciences with proven record of accomplishment. Experience in Mycobacterium model organisms (M. tuberculosis, M. smegmatis, M. bovis BCG, etc.) is highly appreciated.Industrial or CRO experience in whole bacterial cell screen against small molecule library is preferred. Animal model and/or pharmacology experience would be a plus.

• Have at least five years of experience and in-depth understanding of general microbiology, bacterial genetics, and microbial biochemistry.

• Highly self-motivated, and be willing to work diligently in a collaborative and dynamic team environment. Strong oral and written capability in English.

• Result driven, multi-task, communicate clearly and present in a professional manner.

• Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Key Responsibilities

As a senior biologist, you will play key roles in target evaluation/validation, hit identification, hit validation and MOA studies in drug discovery process. Your responsibilities include, but not limit to the following：

• Apply biology and cellular pharmacology knowledge and skills to design and execute biochemical and in vitro cellular experiments involving the evaluation of small molecule modulators.

• Develop and validate a variety of cellular assays to understand the target of interest and characterize small molecule inhibitors/activators.

• Establish robust screening assays to support medicinal chemistry lead optimization programs and contribute to DC (development candidate) identification for ongoing drug discovery projects.

• Design and manage in vivo pre-clinical pharmacokinetics, pharmacodynamics, and toxicity studies.

• Coach and develop research associate/junior scientist in experimental design, data management and analysis.

• Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.

• Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals.

• Maintain and routinely employ in-depth knowledge of project-related scientific literature

Minimum Requirements

• PhD in Biology, physiology, pathology or pharmacology with relevant postdoctoral experience and at least 3 years biotech/pharma working experiences.

• Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, and interrogating cellular signal transduction pathways.

• Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.

• Strong background in designing in vivo animal studies.

• Strong knowledge of cell cycle arrest, apoptosis, and senescence

• Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

• Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Key Responsibilities

• Develop and perform cellular/phenotypic assays for HTS and other biological experiments.

• Analyze data and work together with chemists to evaluate compound potency by various assays.

• Target identification, validation and MOA study.

• Facilitate both internal and external collaborations and provide scientific expertise across functions/teams.

Basic Qualifications

• PhD with 0-5 years of experience in microbiology, immunology or related discipline.

• Experience in host-pathogen interaction or cellular immunology is highly appreciated. Hands-on experience in assay development and HTS would be a plus.

• Candidates must be highly self-motivated and have good communication skills to work in a collaborative and dynamic team environment. Oral and written ability in English is required.

• Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Responsibilities:

• Assist other scientists in biochemistry and cell biology assay developments

• Be responsible for routine experiments and maintenance as assigned by the supervisor, strictly abide by the standard operating procedures.

• Be responsible for data collection, analysis, and keeping a high-quality experimental record

• Present routine works at internal meetings

Qualifications

• MS or BS degree with 0-6 years of relevant working experience in molecular biology/cell biology/biochemistry is required

• Solid skills in molecular/biochemical/cell biology such as molecular cloning, PCR, RT-PCR, protein extraction, and western blot is desirable

• Experience in cell-based screening assays and luciferase reporter assays and small molecule drug discovery is a plus but not required

• Candidates must be highly self-motivated and have good communication skills to work in a collaborative and dynamic team environment.

• Scientific integrity is a must; candidate should be professional in maintaining lab notebooks and electronic files.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Key Responsibilities

• Lead the medicinal chemistry activities of one or more small-molecule drug discovery projects at target validation, hit to lead or lead optimization stages.

• Work together with core team members across multiple disciplines to design and implement project strategies for the advancement of projects leading to the identification of high-quality preclinical candidates.

• Independently design biologically active molecules and conduct SAR studies to meet the project goals; design synthetic routes and lead the internal or external chemistry team in the synthesis and characterization of drug candidates for the projects.

• Work with computational chemistry group to develop structure-based target molecules for projects.

• Proactively communicate project strategy, critical issues and recommendations to enable appropriate resource decisions.

• Provide supervision, scientific mentorship and technical training of the team members.

• Maintain excellent communication across internal and external team members.

Minimum Requirements

• Ph.D. in chemistry or related discipline.

• A minimum of five years of experience in medicinal chemistry required; candidates with demonstrable hands-on small molecule drug discovery and pre-clinical development experience in pharmaceutical/biotech industry highly desired.

• Strong track record of individual and team-level contributions to the discovery and pre-clinical development of small molecule clinical candidates supported with high impact publications, oral presentations and patent applications.

• Excellent background and expertise in organic chemistry with a high level of synthetic skill including novel route design is essential.

• Demonstrated project leadership experience in leading all stages of small molecule drug discovery with the ability to define strategy and critical decision making.

• Excellent problem solving and interpersonal skills with the ability to work well with members of the research and management teams in a dynamic and highly collaborative environment.

• Experience in leading and collaborating with chemistry teams from CROs is a plus but not required.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Key Responsibilities

• Act as a leader in the laboratory, executing on program and chemistry strategy.

• Independently design and carry out efficient synthesis, purification and characterization of drug candidates for target validation, hit-to-lead and lead optimization projects.

• Develop and apply innovative synthetic and medicinal chemistry problem solving skills to build structure-activity relationships.

• Work under supervision of senior members to design biologically active molecules and conduct SAR studies to meet the project goals.

• Work with computational chemistry group to develop structure-based target molecules for projects.

• Provide scientific mentorship and technical training of the team members.

• Supervise and manage the external chemistry team to execute all chemistry plan on projects with superb performance.

• Establish a substantial external scientific presence including authoring significant scientific publications and presentations.

Minimum Requirements

• Ph.D. in chemistry or related discipline with a minimum of one-year industry experience in drug discovery.

• Strong background and experience in organic chemistry (methodology, catalysis, total synthesis etc) is required, along with a proven track record of solving complex problems.

• Good problem solving and interpersonal skills with the ability to work well with members of the research teams in a dynamic and highly collaborative environment.

• Experience in leading and collaborating with CRO chemistry teams is a plus.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Responsibilities:

• Apply his/her expertise and experience in molecular biology, protein chemistry and structure biology to provide high-quality proteins to other drug-discovery functions, including disease biology, HTS and Structure Biology for assay development, biochemical and biophysical characterization.

• Be proficient to use bioinformatic genetic data analysis, protein structure-function studies to design protein constructs for optimized protein expression in various expression systems, preferably proficient in using insect cells, mammalian cell expression systems.

• Be result-oriented, be able to independently design and execute the experiments; maintain accurate laboratory records on research data and operational details.

• As a biochemist, capable of integration of various molecular biology, biochemical, biophysical characterization tools for drug target characterization.

• Be a good team-player, willing to collaborate, actively communicate and eagerly learn new technologies.

Qualifications

Minimal Requirement:

• A Ph.D degree or a MS degree with minimum of 3-5-year post-graduate working experience in the fields of Biochemistry and Biophysics, Structural Biology, Molecular Biology or any related fields.

Preferred to have:

• Experiences with structure determination techniques, including x-ray crystallography, cyro-EM or NMR is preferred.

• Extensive hands-on experiences in molecular biology techniques, recombinant protein production in various expression systems.

• An in-depth knowledge on protein biochemistry and biophysics is a must. Hands-on experiences in biophysical characterization techniques, including SPR, MST, DLS, DSP is a plus.

• Experience with molecular modeling, protein structure determination software, such as Phenix, COOT, CCP4, RELION, ability to use common structural visualization tools, including Pymol, for sharing structural information and structure analysis, is a plus.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

Responsibilities:

• Apply expertise in protein expression/production, biochemistry/biophysical characterization, protein structure-function elucidation to aid the drug-discovery process at GHDDI.

• Work closely with Structure Biology Team members for integrated efforts for high quality and high efficiency protein production and protein characterization, structure determination research efforts, to provide key insights protein-functions analysis.

Qualifications

• A MS degree with minimum of 3-5-year post-graduate working experience in the fields of Biochemistry and Biophysics, Structural Biology, Molecular Biology or any related fields.

• Have extensive hands-on experiences in molecular biology techniques, recombinant protein production in various expression systems.

• Proficient in various chromatography protein purification methods and protein characterization techniques. Hands on experiences with CD, DLS, MST and SPR protein analytic methods is a plus.

• In-depth knowledge on protein biochemistry and biophysics is preferred.

• Familiarity with structure determination techniques, including x-ray crystallography, cyro-EM or NMR is a plus.

• Be result-oriented, be able to independently design and execute the plans for protein construct design, expression and characterization.

• A good team-player, willing to collaborate, actively communicate, eagerly learn new technologies and share knowledge.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop assays and carry out screening campaigns for internal projects and external collaborations. Additional support of other areas including cell culture and molecular biology is expected, when required.

Key Responsibilities

• Design and develop fit for purpose assays in close collaboration with Disease Biology colleagues.

• Support all aspects of assay development and screening including optimization and validation of assays to be executable on automation systems.

• Carry out and troubleshoot a variety of binding and competition assays, using techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

• Use liquid handling automation to support high throughput screening.

• Contribute to and support process improvements.

• Support data management by analyzing data and recording within laboratory notebooks.

• Prepare reports and recommendations to be shared with project teams and collaborators.

• Assist other areas of related functions, including cell culture and molecular biology, when required.

• Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.

Minimum Requirements

• PhD/MS in biological sciences (or equivalent).

• Experience in high throughput strategies from assay design to screening execution.

• Ability of follow and write standard operating procedures.

• Outstanding organizational and time management skills.

Preferred Qualifications

• PhD with a minimum of 3 years (or MS with 8+ years) of working experience in biochemical and/or cellular assay development and screening.

• Track record of contributing to successful outcomes on projects in academia and/or the Biotech/Pharma industry.

• Skilled in the use of high throughput screening strategies, assay cascade design, assay development, screening campaign, and data analysis.

• Detailed knowledge and understanding of technical principles, literature, and methods.

• Experience of applying data analytic theories such as multi-parameter curve fitting and EC / IC50 is required.

• Must possess and demonstrate strong written and verbal communication skills.

• Must be highly self-motivated and can work effectively in a collaborative team environment.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop/optimize assays and carry out screening campaigns for internal projects, collaborations, and services to external customers. Additional support of other areas including cell culture and molecular biology is expected.

Key Responsibilities

• Design and develop fit for purpose assays in close collaboration with disease biology colleagues.

• Support all aspects of assay development and screening activities including assay optimization, validation, and execution on automation systems.

• Test and troubleshoot a variety of assay types, e.g. binding and competition assays, may use techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

• Use liquid handling automation to support high throughput screening.

• Contribute to laboratory process improvements.

• Support data management by analyzing data and recording within laboratory notebooks.

• Prepare reports and share with/present to project teams and collaborators.

• Assist related functions, e.g. cell culture, molecular biology, when required.

• Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.

Minimum Requirements

• MS in biological sciences (or equivalent) with 3 years of post-school laboratory working experience.

• Ability of follow instructions and create standard operating procedures.

• Good organizational and time management skills.

Preferred Qualifications

• MS with 5+ years or PhD with 2+ years of working experience in academic laboratories, CROs, or biotech/pharmaceutical industry.

• Track record of contributing to successful outcomes on projects

• Experiences in developing assays and/or carrying out screening campaigns for drug discovery are highly desired.

• Comprehensive knowledge, understanding, and experience of modern liquid handling technologies is a big plus.

• Experience of carrying out data analysis such as multi-parameter curve fitting, EC50/IC50 determination, or using excel macro to handle large dataset is advantageous.

• Must possess and demonstrate strong written and verbal communication skills.

• Must be highly self-motivated and can work effectively in a collaborative team environment.

Location

Beijing, China

About Us

Global Health Drug Discovery Institute (GHDDI) in Beijing is jointly founded by the Bill & Melinda Gates Foundation, Tsinghua University and Beijing Municipal Government. GHDDI aims to build a transformative drug discovery and translational platform with advanced biomedical research and development capabilities. It is an independent, not-for-profit organization with a broad interest in addressing global health concerns, regardless of financial incentives, and intends to focus its efforts on tackling the world’s most pressing disease challenges faced by many developing countries.

GHDDI provides comprehensive compensation and benefit packages as well as a growing, robust and diverse work environment for motivated and talented individuals who share GHDDI’s vision, and are committed to making a difference in science and human healthcare.

Contact

If you are interested in these exciting opportunities at GHDDI, please submit your CV with a cover letter to career@ghddi.org. 

 * The position is eligible for "Employee Referral Program".

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