About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop/optimize assays and carry out screening campaigns for internal projects, collaborations, and services to external customers. Additional support of other areas including cell culture and molecular biology is expected.

Key Responsibilities

• Design and develop fit for purpose assays in close collaboration with disease biology colleagues.

• Support all aspects of assay development and screening activities including assay optimization, validation, and execution on automation systems.

• Test and troubleshoot a variety of assay types, e.g. binding and competition assays, may use techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

• Use liquid handling automation to support high throughput screening.

• Contribute to laboratory process improvements.

• Support data management by analyzing data and recording within laboratory notebooks.

• Prepare reports and share with/present to project teams and collaborators.

• Assist related functions, e.g. cell culture, molecular biology, when required.

• Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.

Minimum Requirements

• MS in biological sciences (or equivalent) with 3 years of post-school laboratory working experience.

• Ability of follow instructions and create standard operating procedures.

• Good organizational and time management skills.

Preferred Qualifications

• MS with 5+ years or PhD with 2+ years of working experience in academic laboratories, CROs, or biotech/pharmaceutical industry.

• Track record of contributing to successful outcomes on projects.

• Experiences in developing assays and/or carrying out screening campaigns for drug discovery are highly desired.

• Comprehensive knowledge, understanding, and experience of modern liquid handling technologies is a big plus.

• Experience of carrying out data analysis such as multi-parameter curve fitting, EC50/IC50 determination, or using excel macro to handle large dataset is advantageous.

• Must possess and demonstrate strong written and verbal communication skills.

• Must be highly self-motivated and can work effectively in a collaborative team environment.

Location

Beijing, China

主要职责

• 研究小分子抗细菌化合物的作用机理, 用系统生物学特别是代谢组学和基因组学的方法确立药物靶点并进行验证。
• 设计合成或生物合成小分子化合物探针对药物靶点在分子和细胞水平进行研究。
• 开发可用于药物筛选的分子与生化反应体系，特别是细菌基因的转录翻译过程, 和细菌的细胞壁合成与能量代谢途径。
• 广泛阅读抗感染类药物开发文献，为启动小分子药物发现新项目贡献深入独到的见解，并积极整理展示项目进展。

任职要求

• 已取得化学生物学，分子生物化学，酶学，遗传代谢及相关的微生物科学博士学位，最好具有2年以上的博后及项目管理经历。     
• 熟悉生物分子分析技术并使用过各类分析仪器手段包括LCMS，SPR，MST或大分子NMR等，有优良的数据分析能力的申请人会被优先考虑。
• 具备良好的团队合作精神，优秀的协作能力和英文沟通能力包括流利的英文汇报。        
• 应聘者必须具备严谨的科研素质，并能严格地注重专业细节。

工作地：北京市海淀区永泰庄北路1号

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