加入我们

GHDDI正在迅速成长,拥有杰出药物研发能力的人才团队是中心发展的基石。我们欢迎有突出能力的科研人员、有经验的管理者及专业运营人员加入我们。GHDDI为积极主动、有创造力和创业精神的员工提供多元化、充满活力的工作环境以及良好的发展机会。我们的员工认同GHDDI的使命,分享共同的愿景,携手致力科学和人类健康事业的发展。

有求职意向者请将简历发送至:career@ghddi.org.
助理研究员/研究员,试验开发与筛选  

About the Role

    The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop/optimize assays and carry out screening campaigns for internal projects, collaborations, and services to external customers. Additional support of other areas including cell culture and molecular biology is expected.


Key Responsibilities

  • Design and develop fit for purpose assays in close collaboration with disease biology colleagues.

  • Support all aspects of assay development and screening activities including assay optimization, validation, and execution on automation systems.

  • Test and troubleshoot a variety of assay types, e.g. binding and competition assays, may use techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

  • Use liquid handling automation to support high throughput screening.

  • Contribute to laboratory process improvements.

  • Support data management by analyzing data and recording within laboratory notebooks.

  • Prepare reports and share with/present to project teams and collaborators.

  • Assist related functions, e.g. cell culture, molecular biology, when required.

  • Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.


Minimum Requirements

  • MS in biological sciences (or equivalent) with 3 years of post-school laboratory working experience.

  • Ability of follow instructions and create standard operating procedures.

  • Good organizational and time management skills.


Preferred Qualifications

  • MS with 5+ years or PhD with 2+ years of working experience in academic laboratories, CROs, or biotech/pharmaceutical industry.

  • Track record of contributing to successful outcomes on projects

  • Experiences in developing assays and/or carrying out screening campaigns for drug discovery are highly desired.

  • Comprehensive knowledge, understanding, and experience of modern liquid handling technologies is a big plus.

  • Experience of carrying out data analysis such as multi-parameter curve fitting, EC50/IC50 determination, or using excel macro to handle large dataset is advantageous.

  • Must possess and demonstrate strong written and verbal communication skills.

  • Must be highly self-motivated and can work effectively in a collaborative team environment.



工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究助理/高级研究助理,试验开发与筛选  

About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop/optimize assays and carry out screening campaigns for internal projects, collaborations, and services to external customers. Additional support of other areas including cell culture and molecular biology is expected.


Key Responsibilities

  • Develop fit for purpose assays in close collaboration with disease biology colleagues.

  • Support all aspects of assay development and screening including assay optimization, validation, and carrying out screening campaigns on automation systems.

  • Test and troubleshoot a variety of assay types, e.g. binding and competition assays, may use techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

  • Use liquid handling automation to support high throughput screening.

  • Contribute to laboratory process improvements.

  • Organize laboratory data, carry out data analysis, and record results in laboratory notebooks.

  • Prepare reports for project teams and collaborators.

  • Assist related functions, e.g. cell culture, molecular biology, when required.

  • Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.


Minimum Requirements

  • MS in biological sciences (or equivalent) with 1 year of post-school laboratory working experience.

  • Ability of follow instructions and create standard operating procedures.

  • Good organizational and time management skills.


Preferred Qualifications

  • MS with 3 years or more working experience in academic laboratories, CROs, or biotech/pharmaceutical industry.

  • Track record of contributing to successful outcomes on projects

  • Experiences in assay development and/or compound screening are highly desired.

  • Basic knowledge, understanding, and experience of automated liquid handling technologies is a big plus.

  • Experience of carrying out data analysis such as multi-parameter curve fitting, EC50/IC50 determination, or using excel macro to handle large dataset is advantageous.

  • Must possess and demonstrate strong written and verbal communication skills.

  • Must be highly self-motivated and can work effectively in a collaborative team environment.



工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究助理,药代动力学  

主要职责

  • 作为新药研发药代动力学平台的一员,在工作需要时配制PK,药效和毒理所需制剂。

  • 参加DMPK-毒理组日常工作,包括对CRO联系DMPK,药效,毒理的外包项目。

  • 参与培训,学习药代动力学/毒理/制剂等相关知识。


任职要求

  • 本科或硕士学位,有化学和生物教育背景

  • 有如下经验或知识更好:

  • - 对DMPK有了解

    - 懂得分析工作和分析工具如HPLC, MS

    - 了解动物给药制剂配制

  • 能够阅读英文有关文献。

  • 掌握相关办公软件 (Word, Excel, PowerPoint等)。

  • 有团队合作精神和人际沟通能力。

GHDDI提供相关培训,如药物代谢动力学、毒理、制剂等相关知识


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

(高级)研究员及以上,免疫学  

Responsibilities:

    Responsibilities:

    The duties of this position will involve supporting and/or leading a multidisciplinary team to develop vaccines for infectious diseases and utilizing in vivo mouse models with in vitro cell-based immunoassays to elucidate mechanism of action of these vaccines. The ideal candidate will have in-depth and hands-on expertise in immunoassays, flow cytometric analysis of immune cells and in utilizing in vivo mouse models. The candidate must be able to work both independently and collaboratively in a matrixed environment to design, execute, interpret and communicate studies for one or more projects utilizing good scientific judgment and strong team skills. Prior supervisory experience is preferred.

  • Expertise in current technology practices in immunology is required.

  • Experience in Immunoassays Is Required.

  • Experience in Flow Cytometry Is Required.

  • Experience with in vivo rodent models is required.

  • Ability to independently design experiments, make detailed observations, analyze data, interpret results and deliver timely results.

  • Excellent presentation and oral and written communication skills.

  • Proven ability to prepare precise technical summaries and protocols and maintenance of appropriate documentation.

  • Ability to prioritize and work in a fast-paced and diverse environment.

  • Strong sense of urgency, initiative, ethics/integrity and innovation is required.

  • Experience in nucleic acid (mRNA or DNA) vaccination is preferred.

  • Experience in infectious diseases or cancer target or drug discovery is preferred.

  • Integrity/Ethics

  • Initiative

  • Sense of Urgency

  • Teamwork

  • This role requires hands-on laboratory work employing aseptic technique, standard molecular and microbial process with limited exposure to inorganic and organic compounds


Qualifications

  • Ph.D. in appropriate discipline required (e.g., immunology, cell biology, molecular biology)

  • Minimum 2-6 years’ experience (industry experience preferred)

  • Excellent verbal and written communication/Presentation skills, in addition to excellent organizational skills.

  • All qualified applications will receive consideration for employment without regard to race, color, religion, sex, national origin, protected veteran status, or disability status.


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

资深研究员及以上,肠道健康/疾病  

主要职责

  • Lead the team for drug discovery projects in the field of gut health/disease (Initiate/ Plan/Supervise/Lead research projects)

  • Contribute innovatively to any investigative aspect including but not limited to gut barrier, inflammatory, immunology and microbiota.

  • Drive research strategy, identify and assess opportunities for target activity and drug mechanisms of action as it relates to treatment and prevention of gut diseases.

  • Coach, motivate and manage team personnel.

  • Propose and integrate new ideas/technologies (such as organoid) into drug discovery process.

  • Provide expertise and work cooperatively platform teams and other project teams within organization and with external partners/CROs.

  • Contribute to overall disease biology and R&D portfolio as a senior scientific leader


任职要求

  • Ph.D. in Immunology, cell biology, Biomedical Sciences or related areas required with a record of demonstrated productivity.

  • Postdoctoral/working experience in gut health area required (such as inflammatory bowel disease/IBD, celiac disease, irritable bowel syndrome, environmental enteric dysfunction and other intestinal health problems). The expertise/experiences in biomarker determination and in vitro and in vivo model development are preferred

  • Minimum 6 years of experience in drug discovery or industry; experiences in small molecule and/or in natural product are preferred

  • Record of success to identify, evaluate, propose and develop new therapeutic approaches into individual project(s) as well as the overall program.

  • Openminded and innovative in new strategy and technology

  • Oral and written skills in English is required.

  • Scientific integrity is a must


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

微生物学家&免疫学家(多个级别),疾病生物学  

主要职责

  • 开发实验方法,执行高通量筛选和其他生物实验

  • 分析实验数据,同化学家一起对化合物进行潜力评估

  • 靶点识别,验证和机制研究

  • 与内外部其他部门/团队密切合作并提供专业意见


任职要求

  • 微生物学,免疫学,细胞生物学或其他相关专业, 博士学历,0-5年工作经验

  • 具有宿主-细菌相互作用或细胞免疫学经验者优先,具有实验方法开发和高通量筛选经验者优先

  • 对科研工作有热情及兴趣,富有团队合作精神, 适应在动态的,多部门合作的环境中工作,具有良好的英语沟通交流能力。

  • 工作严谨诚信,有良好的实验记录习惯


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究员/高级研究员,药物化学  

主要职责

  • Act as a chemistry project leader to support a drug discovery and development program from target validation to IND, including tool compound discovery, hit-to-lead, lead optimization, preclinical candidate selection, PK/PD studies, IND enabling tox study, and clinical drug candidate selection.

  • Design bioactive and drug-like new chemical entities (NCEs); Create feasible and cost-effective synthetic schemes; Direct CRO to synthesize drug candidates in a timely manner; Deliver high quality drug candidates and achieve program milestones.

  • Synthesize complex bioactive compounds and trouble shoot synthetic organic chemistry problem.

  • Work with internal biology team, computer-aided drug design (CADD) team, and artificial intelligence drug discovery (AIDD) team to build structure activity relationship (SAR) and structure property relationship (SPR) for a medical chemistry library to deliver high quality drug candidates for an druggable oncology or neurological target.

  • Communicate effectively with CRO to execute all chemistry plan in a timely manner.

  • Present research results effectively orally and in writing to internal stakeholders and general scientific community.


任职要求

  • Ph.D. in synthetic organic chemistry, medicinal chemistry, chemical biology, or related discipline.

  • Industrial experiences (1 to 5 years) in drug discovery or CRO environment is a plus.

  • Strong background and experience in synthetic organic chemistry is required, along with a proven track record of solving complex problems.

  • Good problem solving and interpersonal skills with the ability to work well with members of the research teams in a dynamic and highly collaborative environment.


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究员/资深研究员,疾病生物学  

主要职责

  • Responsible for genetic manipulation with Mycobacterium and/or other bacterial pathogens, developing phenotypic assays and HTS for antibacterial.

  • To identify antibacterial drug target, analyze the mode-of-action of small molecule, and bacterial strain typing and genome sequence analysis.

  • Develop knowledge to strengthen the medical and pharmaceutical aspects of the projects.

  • Facilitate both internal and external collaborations, and provide scientific expertise across functions/teams.


任职要求

  • PhD degree in microbiology or the related biological sciences with proven record of accomplishment. Experience in Mycobacterium model organisms (M. tuberculosis, M. smegmatis, M. bovis BCG, etc.) is highly appreciated.Industrial or CRO experience in whole bacterial cell screen against small molecule library is preferred. Animal model and/or pharmacology experience would be a plus.

  • Have at least five years of experience and in-depth understanding of general microbiology, bacterial genetics, and microbial biochemistry.

  • Highly self-motivated, and be willing to work diligently in a collaborative and dynamic team environment. Strong oral and written capability in English.

  • Result driven, multi-task, communicate clearly and present in a professional manner.

  • Scientific integrity is a must, candidate should be professional in maintaining lab notebooks and electronic files.


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

高级研究员,细胞生物学  

主要职责

As a senior biologist, you will play key roles in target evaluation/validation, hit identification, hit validation and MOA studies in drug discovery process. Your responsibilities include, but not limit to the following

  • Apply biology and cellular pharmacology knowledge and skills to design and execute biochemical and in vitro cellular experiments involving the evaluation of small molecule modulators.

  • Develop and validate a variety of cellular assays to understand the target of interest and characterize small molecule inhibitors/activators.

  • Establish robust screening assays to support medicinal chemistry lead optimization programs and contribute to DC (development candidate) identification for ongoing drug discovery projects.

  • Design and manage in vivo pre-clinical pharmacokinetics, pharmacodynamics, and toxicity studies.

  • Coach and develop research associate/junior scientist in experimental design, data management and analysis.

  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way.

  • Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals.

  • Maintain and routinely employ in-depth knowledge of project-related scientific literature


任职要求

  • PhD in Biology, physiology, pathology or pharmacology with relevant postdoctoral experience and at least 3 years biotech/pharma working experiences.

  • Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, and interrogating cellular signal transduction pathways.

  • Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.

  • Strong background in designing in vivo animal studies.

  • Strong knowledge of cell cycle arrest, apoptosis, and senescence

  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究员,药物化学  

主要职责

  • 负责在实验室中领导并执行研究项目的化学发展战略。

  • 在靶点验证阶段、先导阶段和优化阶段的研究项目中独立设计和开展候选药物的高效合成、纯化和表征。

  • 开发并应用创新的合成手段及药物化学专业技能,构建构效关系。

  • 在团队资深成员的监督指导下设计生物活性分子,并开展SAR研究以达成项目目标。

  • 与计算化学团队紧密合作,开发基于结构的靶点分子。

  • 为团队成员提供科学指导和技术培训。

  • 监督并管理外部化学团队以高质量执行研究项目中的化学计划。

  • 扩大机构对外的学术影响力,包括撰写科学出版物和演示文稿。


任职要求

  • 已取得化学或相关领域的博士学位,以及至少1年的药物研发行业经验。

  • 应聘者必须具有优秀的有机化学背景和专业知识(方法、催化、全合成等),以及解决复杂问题的丰富经验。

  • 优秀的解决问题能力及人际沟通能力,能在团队环境中与机构其他的研发或管理人员高效协同工作。

  • 具有良好的领导或与CRO的化学团队合作经验更佳。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究助理,药物化学  

主要职责

包括但不限于:

  • 在靶点验证阶段、先导阶段和优化阶段的研究项目中独立开展候选药物的高效合成、纯化和表征。

  • 在团队资深成员的监督指导下参与生物活性分子的实验设计,并协助完成项目相关报告。

  • 基于项目进行常规化合物表征及纯度分析。

  • 使用并维护实验室设备;并能遵循规则对实验记录和文档进行归档整理。

  • 与相关团队紧密合作,推动项目进程。


任职要求

  • 已取得化学或相关领域的硕士学位,药物研发行业经验优先。

  • 应聘者必须具有优秀的有机化学背景和专业知识(方法、催化、全合成等),以及解决复杂问题的丰富经验。

  • 应聘者需熟悉并熟练掌握化学仪器设备 (NMR, LCMS等)及化学相关办公软件(Chemoffice, Word, Excel, PowerPoint等)。

  • 优秀的解决问题能力及人际沟通能力,能在团队环境中与机构其他的研发或管理人员高效协同工作。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

资深研究员及以上,药物化学  

主要职责

  • 领导一个或多个小分子药物研发项目在靶点验证、先导阶段和优化阶段中的药物化学工作。

  • 与跨学科的核心研发团队成员协作,设计并实施研发项目发展战略,以推进项目成功取得高质量临床前候选化合物。

  • 独立从事药物分子设计与构效关系研究,以完成设定的项目目标;设计合成路线,并引领研究中心和外部合作伙伴公司的化学团队合成与鉴定候选药物。

  • 与计算化学团队紧密合作,设计基于结构的靶标分子。

  • 积极沟通项目的发展战略和关键问题,以做出合适的资源决策。

  • 管理和监督团队工作,并为团队成员提供科学指导和技术培训。

  • 与研究中心内部和外部的研究团队建立高效的沟通机制。


任职要求

  • 已取得化学或其他相关领域的博士学位。

  • 应聘者须具备五年以上在药物化学领域的工作经历;具有在制药/生物科技行业小分子药物研发的实践经验及临床前研发经验的应聘者将获得优先考虑。

  • 在小分子候选药物的临床前研发方面有着突出的个人与团队贡献,包括发表过高水平的学术论文,口头报告与专利申请等。

  • 具有优秀的有机化学背景和专业知识,以及包括新合成路线设计能力等高水平的合成技能。

  • 具有项目领导经验以及在小分子药物研发的各阶段制定战略和重要决策的能力。

  • 优秀的解决问题能力及人际沟通能力,能在团队环境中与机构其他的研发或管理人员高效协同工作。

  • 具有良好的领导或者与CRO的化学团队合作经验更佳。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

研究员/资深研究员(生物化学家 & 药物学家),疾病生物学  

主要职责

  • 研究小分子抗生素化合物的作用机理。

  • 用系统生物学和各类组学的方法确立药物靶点并进行验证。

  • 开发可用于药物筛选的分子与生化反应体系,特别是细菌基因的转录翻译过程, 和细菌的细胞壁合成与能量代谢途径。

  • 开发实验动物细菌感染模型用于靶点和小分子药物的研究。


任职要求

  • 已取得分子生物化学,微生物遗传,医学微生物,动物兽医或相关生物科学硕士或博士学位,具有0-6年相关经历。

  • 具有研究细菌传染病和实验动物模型的科研经历,和有优良的数据分析能力的申请人会被优先考虑。

  • 具备良好的团队合作精神,优秀的协作能力和英文沟通能力。

  • 应聘者必须具备严谨的科研素养,并能严格对实验记录和电子文档进行归档整理。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

资深研究员及以上,微生物学家及项目经理  

主要职责

  • Lead drug development team/projects of anti-TB and other infectious disease areas in discovery to preclinical stages to reach critical G0/NoGo decisions, milestones and deliverable goals

  • Participate and play a key role in disease biology for strategy and plan set up, collaboration with global partners, and evaluation of external opportunities

  • Work closely with medicinal chemistry, structural biology, and DMPK teams to identify and promote promising hits through discovery and development stages.

  • Plan and drive all microbiology studies to meet anti-TB drug stage criteria

  • Initiate, facilitate, and organize domestic and international collaborations with academic and industrial partners.

  • Develop written reports and oral presentations for monthly and quarterly meetings and annual reports.

  • Present findings in domestic and international meetings and publish on scientific journals.


任职要求

  • Have a Ph.D. in microbiology/bacteriology and/or molecular biology with a minimum 5 to 10 years working experiences in drug discovery and development.

  • Experiences in pharmaceutical industry or CRO in the field of antibacterial drug R&D is preferred. The experiences in leading project team in industry is highly appreciated.

  • Have a broad and deep understandings of cutting-edge technologies and challenges in anti-microbial, particularly TB, drug discovery and development

  • Have oral and written English communication skills to meet the requirement of this position

  • Be capable of working in and contributing to an interactive and multidisciplinary team environment

  • Possess excellent team management skills and the ability to interact effectively with an international network of laboratories and disease experts.

  • Be meticulous in maintaining lab notebooks and data files.

  • The applicants should demonstrate a proven track record of scientific achievements and creative problem-solving skills.

  • Those with in-depth knowledge in genome editing, chemical biology, systems biology, parasite genomics, biomarker discovery, host immunity, vector biology, or in vivo animal model studies will be preferred.

  • Hands-on experiences in vitro cell culture, microscopy, flow cytometry, and molecular biology are ideal, but not required.


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

资深研究员及以上,细胞生物学  

主要职责

  • Create, develop and validate quantitative mammalian cellular assays to address the project team’s mechanistic and functional needs.

  • Establish robust screening assays to support medicinal chemistry lead optimization programs.

  • Design and manage in vivo pre-clinical pharmacokinetics, pharmacodynamics, and toxicity studies.

  • Design and manage physiological experiments in translational disease models to test efficacy and mechanism of action of novel clinical candidates.

  • Establish PK/PD relationships, demonstrating proof-of-concept, enabling candidate selection and delivering data for clinical dose predictions in preclinical in vivo experiments.

  • Establish pharmacology strategy in alignment with company pipeline objectives.

  • Proactively investigate new or different technologies, methods, and service providers to ensure our work is being done in a scientifically sound, efficient, and reasonable way

  • Bring forward innovative ideas, novel translational animal models and advanced technologies to support team goals.

  • Identify, evaluate, and manage vendors for outsourced services and studies.

  • Prepare reports for internal and external purposes including regulatory submissions.

  • Participate and lead project-based and technical team meetings to identify and solve problems, guide work towards project goals, communicate on-going work and progress, and plan forward thinking strategies.

  • Develop and continually advance one’s knowledge base on the molecular pathways being targeted by discovery and development research programs.

  • Identify opportunities and develop ideas to enhance and accelerate business processes.

  • Cultivates cross-functional relationships with project teams, translational medicine, biomarker teams, and disease-specific working groups to deliver novel targets, biomarkers and drug candidates.

  • Responsible for achieving pipeline goals by managing resource allocation and oversight of progress.

  • Present scientific accomplishments internally and externally to the scientific community and discussed with key opinion leaders.

  • Responsible for career development of team of diverse scientists, contribute to talent strategy and provide mentorship to group.


任职要求

  • PhD in Biology, physiology, pathology or pharmacology with relevant postdoctoral experience and at least 5 years biotech/pharma working experiences.


择优要求

  • Extensive experience in creating, developing, and running cellular assays; engineering cell lines to express or knock-down genes of interest, and interrogating cellular signal transduction pathways.

  • Experience with flow cytometry and general molecular biological techniques including q-PCR, ELISA, MSD and Western Blot etc.

  • Strong background in designing in vivo animal studies.

  • Strong knowledge of cell cycle arrest, apoptosis, and senescence

  • Experience in oncology and knowledge p53 signaling pathway is a plus

  • Excellent interpersonal skills with ability to communicate and interact well with colleagues, vendors, contractors, scientific advisors, and staff at all levels.

  • Committed to staying current with the latest scientific breakthroughs in the targeted oncology field from target identification through human clinical trials.


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org


* 该职位享有“人才招募推荐计划”。

各级别研究员,传染病学  

主要职责

  • 候选人将和多学科交叉创新团队成员一起,参与开发用于传染病(结核或由HBV, DENV和ZIKV引起的病毒感染)治疗的新药。

  • 利用体外高通量筛选试验来确定候选药物,利用动物模型来评价候选药物的有效性和作用机制。

  • 需要具备良好的科学素养和较强的团队合作能力,能够独立工作以及和团队成员紧密合作,参与免疫研究项目的设计、执行、对结果的解读和项目交流。


任职要求

  • 具有病毒学、免疫学、细胞生物学和分子生物学等相关专业硕士或者博士学位。

  • 有2到8年的相关经验。

  • 优秀的口头表达能力、写作能力和组织能力。

  • 掌握分子生物学, 免疫病毒学相关的实验技能,具有病毒培养、免疫检测等相关实验操作经验。

  • 有结核,HBV, DENV,以及 ZIKV病毒操作经验者、设计和开发过新的病毒筛选试验方法的候选人优先考虑。

  • 在筛选试验方法开发方面拥有丰富的经验和专业知识,能为体外药物筛选提供最佳的高通量筛选试验系统。

  • 能够独立设计实验、解读和分析数据,并且对实验结果进行及时反馈和沟通。


工作地

北京市海淀区永泰庄北路1号


关于我们

全球健康药物研发中心(Global Health Drug Discovery Institute,简称“GHDDI”)是由清华大学和比尔及梅琳达·盖茨基金会发起,北京市科学技术委员会代表北京市人民政府联合出资支持下成立的一个独立运营、非营利性质的全球公共卫生与药物创新机构。中心关注全球健康问题,致力发展杰出的生物医药研究与开发能力,建设新药研发和转化的创新平台,为解决发展中国家面临的突出疾病挑战做出贡献。

GHDDI为员工提供合理薪酬、年假以及全面社保,并致力于创造一个充满活力、包容和多元化的工作环境,使个人拥有快速成长的发展空间和一份有趣、有价值、有使命感的事业!


联系我们

申请者请发送个人简历以及代表性论文清单至 career@ghddi.org。


* 该职位享有“人才招募推荐计划”。